Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hedgehog agonist therapy corrects structural and cognitive deficits in a Down syndrome mouse model.

Science translational medicine - 4 Sept 2013

Das Ishita, Park Joo-Min, Shin Jung H, Jeon Soo Kyeong, Lorenzi Hernan, Linden David J, Worley Paul F, Reeves Roger H

Abstract excerpt

Down syndrome (DS) is among the most frequent genetic causes of intellectual disability, and ameliorating this deficit is a major goal in support of people with trisomy 21. The Ts65Dn mouse recapitulates some major brain structural and behavioral phenotypes of DS, including reduced size and cellu...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Down Syndrome
Share to Maze Learning
Share to Memory

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neuronal Plasticity

Share to Purkinje Cells

Share to Receptors, AMPA

Share to Receptors, N-Methyl-D-Aspartate

Share to Thiophenes

Source

Open in PubMed Open full text

Identifiers

PMID: 24005160
DOI: 10.1126/scitranslmed.3005983
PMCID: PMC4006719

Genes

SAG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24005160-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hedgehog agonist therapy corrects structural and cognitive deficits in a Down syndrome mouse model.PMID 24005160Read ↗

Defective cerebellar response to mitogenic Hedgehog signaling in Down [corrected] syndrome mice.Semantic proximity Read ↗

Overexpression screen of chromosome 21 genes reveals modulators of Sonic hedgehog signaling relevant to Down syndromeSemantic proximity Read ↗

Signalling pathways contributing to learning and memory deficits in the Ts65Dn mouse model of Down syndromeSemantic proximity Read ↗

Maternal choline supplementation improves spatial learning and adult hippocampal neurogenesis in the Ts65Dn mouse model of Down syndromeSemantic proximity Read ↗

A Sonic hedgehog (Shh) response deficit in trisomic cells may be a common denominator for multiple features of Down syndrome.Semantic proximity Read ↗

Pharmacological approaches to improving cognitive function in Down syndrome: current status and considerationsSemantic proximity Read ↗

Mouse Models for Down Syndrome-Associated Developmental Cognitive DisabilitiesSemantic proximity Read ↗

Multisensory gamma stimulation enhances adult neurogenesis and improves cognitive function in male mice with Down SyndromeSemantic proximity Read ↗

A neural crest deficit in Down syndrome mice is associated with deficient mitotic response to Sonic hedgehog.Semantic proximity Read ↗

LONG-TERM NEURODEVELOPMENTAL AND COGNITIVE OUTCOMES FOLLOWING PRENATAL INHIBITION OF DYRK1A BY LEUCETTINE L41 IN MOUSE MODELS OF DOWN SYNDROMESemantic proximity Read ↗

The lncRNA Snhg11, a new candidate contributing to neurogenesis, plasticity and memory deficits in Down syndromeSemantic proximity Read ↗

Overexpression of Dyrk1A Is Implicated in Several Cognitive, Electrophysiological and Neuromorphological Alterations Found in a Mouse Model of Down SyndromeSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.