Article
Adult-onset fluoxetine treatment does not improve behavioral impairments and may have adverse effects on the Ts65Dn mouse model of Down syndrome.
Neural plasticity - 1 Jan 2012
Heinen Markus, Hettich Moritz M, Ryan Devon P, Schnell Susanne, Paesler Katharina, Ehninger Dan
Abstract excerpt
Down syndrome is caused by triplication of chromosome 21 and is associated with neurocognitive phenotypes ranging from severe intellectual disability to various patterns of more selective neuropsychological deficits, including memory impairments. In the Ts65Dn mouse model of Down syndrome, excessive GABAergic neurotransmission results in local over-inhibition of hippocampal circuits, which dampens hippocampal...
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