Article
Increased Regenerative Capacity of the Olfactory Epithelium in Niemann-Pick Disease Type C1.
International journal of molecular sciences - 6 Apr 2017
Meyer Anja, Wree Andreas, Günther René, Holzmann Carsten, Schmitt Oliver, Rolfs Arndt, Witt Martin
Abstract excerpt
Niemann-Pick disease type C1 (NPC1) is a fatal neurovisceral lysosomal lipid storage disorder. The mutation of the NPC1 protein affects the homeostasis and transport of cholesterol and glycosphingolipids from late endosomes/lysosomes to the endoplasmic reticulum resulting in progressive neurodegeneration. Since olfactory impairment is one of the earliest symptoms in many neurodegenerative disorders, we focused on...
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