Article
Germline variation in inflammation-related pathways and risk of Barrett's oesophagus and oesophageal adenocarcinoma.
Gut - 1 Oct 2017
Buas Matthew F, He Qianchuan, Johnson Lisa G, Onstad Lynn, Levine David M, Thrift Aaron P, Gharahkhani Puya, Palles Claire, Lagergren Jesper, Fitzgerald Rebecca C, Ye Weimin, Caldas Carlos, Bird Nigel C, Shaheen Nicholas J, Bernstein Leslie, Gammon Marilie D, Wu Anna H, Hardie Laura J, Pharoah Paul D, Liu Geoffrey, Iyer Prassad, Corley Douglas A, Risch Harvey A, Chow Wong-Ho, Prenen Hans, Chegwidden Laura, Love Sharon, Attwood Stephen, Moayyedi Paul, MacDonald David, Harrison Rebecca, Watson Peter, Barr Hugh, deCaestecker John, Tomlinson Ian, Jankowski Janusz, Whiteman David C, MacGregor Stuart, Vaughan Thomas L, Madeleine Margaret M
Abstract excerpt
OBJECTIVE: Oesophageal adenocarcinoma (OA) incidence has risen sharply in Western countries over recent decades. Local and systemic inflammation is considered an important contributor to OA pathogenesis. Established risk factors for OA and its precursor, Barrett's oesophagus (BE), include symptomatic reflux, obesity and smoking. The role of inherited genetic susceptibility remains an area of active investigation....
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