Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association between targeted somatic mutation (TSM) signatures and HGS-OvCa progression.

Cancer medicine - 1 Sept 2016

Lindley Robyn A, Humbert Patrick, Larner Cliff, Akmeemana Eric H, Pendlebury Christopher R R

Abstract excerpt

Evidence already exists that the activation-induced cytidine deaminase (AID/APOBEC) and the adenosine deaminase (ADAR) families of enzymes are implicated as powerful mutagens in oncogenic processes in many somatic tissues. Each deaminase is identified by the DNA or RNA nucleotide sequence ("motif") surrounding the nucleotide targeted for deamination. The primary objective of this study is to develop an in silico...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biomarkers, Tumor
Share to Cystadenocarcinoma, Serous

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Disease Progression

Share to Genetic Association Studies

Share to Kaplan-Meier Estimate

Share to Neoplasm Grading

Share to Neoplasm Staging

Share to Ovarian Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 27485054
DOI: 10.1002/cam4.825
PMCID: PMC5055158

Genes

HGS
ADAR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association between targeted somatic mutation (TSM) signatures and HGS-OvCa progression.PMID 27485054Read ↗

Signatures of mutational processes in human cancer.Semantic proximity Read ↗

Comprehensive Analyses Identify APOBEC3A as a Genomic Instability-Associated Immune Prognostic Biomarker in Ovarian Cancer.Semantic proximity Read ↗

Mutation burden-orthogonal tumor genomic subtypes delineate responses to immune checkpoint therapySemantic proximity Read ↗

Genomic consequences of aberrant DNA repair mechanisms stratify ovarian cancer histotypes.Semantic proximity Read ↗

Mutational signatures reveal ternary relationships between homologous recombination repair, APOBEC, and mismatch repair in gynecological cancers.Semantic proximity Read ↗

Identification of the Prognostic Significance of a Somatic Mutation-derived Alternative Splicing Signature in Colorectal CancerSemantic proximity Read ↗

APOBEC3B upregulation and genomic mutation patterns in serous ovarian carcinoma.Semantic proximity Read ↗

APOBEC and ADAR deaminases may cause many single nucleotide polymorphisms curated in the OMIM database.Semantic proximity Read ↗

APOBEC3-mediated mutagenesis in cancer: causes, clinical significance and therapeutic potential.Semantic proximity Read ↗

Inherited variants affecting RNA editing may contribute to ovarian cancer susceptibility: results from a large-scale collaboration.Semantic proximity Read ↗

Mutational signature dynamics shaping the evolution of oesophageal adenocarcinoma.Semantic proximity Read ↗

Genomic landscape of adenosquamous carcinoma of the colorectum reveals actionable therapeutic targetsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.