Article
Inherited variants affecting RNA editing may contribute to ovarian cancer susceptibility: results from a large-scale collaboration.
Oncotarget - 8 Nov 2016
Permuth Jennifer B, Reid Brett, Earp Madalene, Chen Y Ann, Monteiro Alvaro N A, Chen Zhihua, Chenevix-Trench Georgia, Fasching Peter A, Beckmann Matthias W, Lambrechts Diether, Vanderstichele Adriaan, Van Niewenhuyse Els, Vergote Ignace, Rossing Mary Anne, Doherty Jennifer Anne, Chang-Claude Jenny, Moysich Kirsten, Odunsi Kunle, Goodman Marc T, Shvetsov Yurii B, Wilkens Lynne R, Thompson Pamela J, Dörk Thilo, Bogdanova Natalia, Butzow Ralf, Nevanlinna Heli, Pelttari Liisa, Leminen Arto, Modugno Francesmary, Edwards Robert P, Ness Roberta B, Kelley Joseph, Heitz Florian, Karlan Beth, Lester Jenny, Kjaer Susanne K, Jensen Allan, Giles Graham, Hildebrandt Michelle, Liang Dong, Lu Karen H, Wu Xifeng, Levine Douglas A, Bisogna Maria, Berchuck Andrew, Cramer Daniel W, Terry Kathryn L, Tworoger Shelley S, Poole Elizabeth M, Bandera Elisa V, Fridley Brooke, Cunningham Julie, Winham Stacey J, Olson Sara H, Orlow Irene, Bjorge Line, Kiemeney Lambertus A, Massuger Leon, Pejovic Tanja, Moffitt Melissa, Le Nhu, Cook Linda S, Brooks-Wilson Angela, Kelemen Linda E, Gronwald Jacek, Lubinski Jan, Wentzensen Nicolas, Brinton Louise A, Lissowska Jolanta, Yang Hanna, Hogdall Estrid, Hogdall Claus, Lundvall Lene, Pharoah Paul D P, Song Honglin, Campbell Ian, Eccles Diana, McNeish Iain, Whittemore Alice, McGuire Valerie, Sieh Weiva, Rothstein Joseph, Phelan Catherine M, Risch Harvey, Narod Steven, McLaughlin John, Anton-Culver Hoda, Ziogas Argyrios, Menon Usha, Gayther Simon, Ramus Susan J, Gentry-Maharaj Aleksandra, Pearce Celeste Leigh, Wu Anna H, Kupryjanczyk Jolanta, Dansonka-Mieszkowska Agnieszka, Schildkraut Joellen M, Cheng Jin Q, Goode Ellen L, Sellers Thomas A
Abstract excerpt
RNA editing in mammals is a form of post-transcriptional modification in which adenosine is converted to inosine by the adenosine deaminases acting on RNA (ADAR) family of enzymes. Based on evidence of altered ADAR expression in epithelial ovarian cancers (EOC), we hypothesized that single nucleotide polymorphisms (SNPs) in ADAR genes modify EOC susceptibility, potentially by altering ovarian tissue gene...
