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Quantitation of Replication-Competent HIV-1 in Populations of Resting CD4 + T Cells

25 Sept 2014

Abstract excerpt

UNLABELLED: Central memory (TCM) CD4(+) T cells are the principal reservoir of latent HIV-1 infection that persists despite durable, successful antiretroviral therapy (ART). In a study that measured HIV DNA in 17 patients and replication-competent HIV in 4 patients, pools of resting and activated transitional memory (T(TM)) CD4(+) T cells were found to be a reservoir for HIV infection. As defective viruses...

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Identifiers

PMID: 25253353
DOI: 10.1128/jvi.01900-14

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