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Article

HIV-1 Residual Viremia Correlates with Persistent T-Cell Activation in Poor Immunological Responders to Combination Antiretroviral Therapy

29 Oct 2009

Abstract excerpt

BACKGROUND: The clinical significance and cellular sources of residual human immunodeficiency virus type 1 (HIV-1) production despite suppressive combination antiretroviral therapy (cART) remain unclear and the effect of low-level viremia on T-cell homeostasis is still debated. METHODOLOGY/PRINCIPAL FINDINGS: We characterized the recently produced residual viruses in the plasma and short-lived blood monocytes of...

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PMID: 19876401
DOI: 10.1371/journal.pone.0007658

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