Article
Phenotypic and Functional Comparison of Class Switch Recombination Deficiencies with a Subgroup of Common Variable Immunodeficiencies.
Journal of clinical immunology - 1 Oct 2016
Aan de Kerk Daan J, Jansen Machiel H, Jolles Stephen, Warnatz Klaus, Seneviratne Suranjith L, Ten Berge Ineke J M, van Leeuwen Ester M M, Kuijpers Taco W
Abstract excerpt
Primary antibody deficiencies (PADs) are the most common immunodeficiency in humans, characterized by low levels of immunoglobulins and inadequate antibody responses upon immunization. These PADs may result from an early block in B cell development with a complete absence of peripheral B cells and lack of immunoglobulins. In the presence of circulating B cells, some PADs are genetically caused by a class switch...
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