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Article

There is no gene for CVID - novel monogenetic causes for primary antibody deficiency.

Current opinion in immunology - 1 Oct 2021

Ramirez Neftali J, Posadas-Cantera Sara, Caballero-Oteyza Andrés, Camacho-Ordonez Nadezhda, Grimbacher Bodo

Abstract excerpt

'There is no gene for fate' (citation from the movie 'GATTACA') - and there is no gene for CVID. Common Variable ImmunoDeficiency (CVID) is the most prevalent primary immunodeficiency in humans. CVID is characterized by an increased susceptibility to infections, hypogammaglobulinemia, reduced switched memory B cell numbers in peripheral blood and a defective response to vaccination, often complicated by...

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Identifiers

PMID: 34153571
DOI: 10.1016/j.coi.2021.05.010

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