Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Characterization of the Methylthioadenosine Phosphorylase Polymorphism rs7023954 - Incidence and Effects on Enzymatic Function in Malignant Melanoma.

PloS one - 1 Jan 2016

Limm Katharina, Dettmer Katja, Reinders Jörg, Oefner Peter J, Bosserhoff Anja-Katrin

Abstract excerpt

Deficiency of methylthioadenosine phosphorylase (MTAP) supports melanoma development and progression through accumulation of its substrate 5'-methylthioadenosine (MTA), which leads amongst others to a constitutive inhibition of protein arginine methyltransferases (PRMTs) and activation of the transcription factor AP-1 via the receptor ADORA2B. Genetic association studies have also suggested that genetic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Enzyme Activation
Share to Incidence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Melanoma

Share to Purine-Nucleoside Phosphorylase

Share to Sequence Analysis, RNA

Share to Spectrometry, Mass, Electrospray Ionization

Share to Tumor Cells, Cultured

Source

Open in PubMed Open full text

Identifiers

PMID: 27479139
DOI: 10.1371/journal.pone.0160348
PMCID: PMC4968798

Genes

MTAP

Variants

rs7023954

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 11 closest

Characterization of the Methylthioadenosine Phosphorylase Polymorphism rs7023954 - Incidence and Effects on Enzymatic Function in Malignant Melanoma.PMID 27479139Read ↗

Characterization of methylthioadenosin phosphorylase (MTAP) expression in malignant melanoma.Semantic proximity Read ↗

Novel O6-methylguanine-DNA methyltransferase SNPs: a frequency comparison of patients with familial melanoma and healthy individuals in Sweden.Semantic proximity Read ↗

TP 53 polymorphisms and melanoma: A meta-analysis.Semantic proximity Read ↗

Identification of two novel sequence variants affecting thiopurine methyltransferase enzyme activity.Semantic proximity Read ↗

Methionine synthase genetic polymorphism MS A2756G alters susceptibility to follicular but not diffuse large B-cell non-Hodgkin's lymphoma or multiple myeloma.Semantic proximity Read ↗

Allelic loss at the p73 locus (1p36.33) is infrequent in malignant melanoma.Semantic proximity Read ↗

Association between a rare novel TP53 variant (rs78378222) and melanoma, squamous cell carcinoma of head and neck and lung cancer susceptibility in non-Hispanic Whites.Semantic proximity Read ↗

Specific Targeting of MTAP -Deleted Tumors with a Combination of 2′-Fluoroadenine and 5′-MethylthioadenosineSemantic proximity Read ↗

Selective Killing of Tumors Deficient in Methylthioadenosine Phosphorylase: A Novel StrategySemantic proximity Read ↗

Temperature-sensitive mutants of p16CDKN2 associated with familial melanoma.Semantic proximity Read ↗

One amino acid makes a difference-Characterization of a new TPMT allele and the influence of SAM on TPMT stability.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.