Thrombin Cleavage of Osteopontin Modulates Its Activities in Human Cells<i>In Vitro</i>and Mouse Experimental Autoimmune Encephalomyelitis<i>In Vivo</i>

Abstract excerpt

Osteopontin is a proinflammatory cytokine and plays a pathogenetic role in multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis (EAE), by recruiting autoreactive T cells into the central nervous system. Osteopontin functions are modulated by thrombin cleavage generating N- and C-terminal fragment, whose individual roles are only partly known. Published data are difficult to compare...

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