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FocalScan: Scanning for altered genes in cancer based on coordinated DNA and RNA change.

Nucleic acids research - 2 Nov 2016

Karlsson Joakim, Larsson Erik

Abstract excerpt

Somatic genomic copy-number alterations can lead to transcriptional activation or inactivation of tumor driver or suppressor genes, contributing to the malignant properties of cancer cells. Selection for such events may manifest as recurrent amplifications or deletions of size-limited (focal) regions. While methods have been developed to identify such focal regions, finding the exact targeted genes remains a...

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PMID: 27474725
DOI: 10.1093/nar/gkw674
PMCID: PMC5100559

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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