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Article

Identification of Noncoding Functional Regulatory Variants of STIM1 Gene in Idiopathic Pulmonary Arterial Hypertension.

Hypertension (Dallas, Tex. : 1979) - 1 Sept 2024

Liu Bingxun, Wen Cen-Jin, Zhou Guangyuan, Wei Yun-Peng, Wu Zeang, Zhang Ting, Zhou Yudan, Qiu Shuyi, Wang Tao, Ruiz Matthieu, Dupuis Jocelyn, Yuan Ping, Liu Jinming, Zhu Liping, Jing Zhi-Cheng, Hu Qinghua

Abstract excerpt

BACKGROUND: STIM1 (stromal interaction molecule 1) regulates store-operated calcium entry and is involved in pulmonary artery vasoconstriction and pulmonary artery smooth muscle cell proliferation, leading to pulmonary arterial hypertension (PAH). METHODS: Bioinformatics analysis and a 2-stage matched case-control study were conducted to screen for noncoding variants that may potentially affect STIM1...

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Share to Cell Proliferation
Share to Familial Primary Pulmonary Hypertension

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation

Share to Muscle, Smooth, Vascular

Share to Myocytes, Smooth Muscle

Share to Neoplasm Proteins

Share to Pulmonary Artery

Share to Stromal Interaction Molecule 1

Source

Identifiers

PMID: 38989583
DOI: 10.1161/HYPERTENSIONAHA.124.22766

Genes

STIM1
PAH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

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Identification of Noncoding Functional Regulatory Variants of STIM1 Gene in Idiopathic Pulmonary Arterial Hypertension.PMID 38989583Read ↗

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