Article
Lynch syndrome in Tunisia: first description of clinical features and germline mutations.
International journal of colorectal disease - 1 Apr 2011
Moussa Sana Aissi-Ben, Moussa Amel, Kourda Nadia, Mezlini Amel, Abdelli Nabil, Zerimech Farid, Najjar Taoufik, Jilani Sarah Ben, Porchet Nicole, Ayed Farhat Ben, Manai Mohamed, Buisine Marie-Pierre
Abstract excerpt
PURPOSE: High rates of early colorectal cancers (CRC) are observed in Tunisia suggesting genetic susceptibility. Nevertheless, up to now, no molecular study has been performed in the Tunisian population. In our research, we evaluated the clinical characteristics of Tunisian families suspected of Lynch syndrome and the contribution of DNA mismatch repair (MMR) genes. METHODS: Thirty-one unrelated families...
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