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Article

Inferring the Mutational History of a Tumor Using Multi-state Perfect Phylogeny Mixtures.

Cell systems - 1 Jul 2016

El-Kebir Mohammed, Satas Gryte, Oesper Layla, Raphael Benjamin J

Abstract excerpt

Phylogenetic techniques are increasingly applied to infer the somatic mutational history of a tumor from DNA sequencing data. However, standard phylogenetic tree reconstruction techniques do not account for the fact that bulk sequencing data measures mutations in a population of cells. We formulate and solve the multi-state perfect phylogeny mixture deconvolution problem of reconstructing a phylogenetic tree...

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PMID: 27467246
DOI: 10.1016/j.cels.2016.07.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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