Article
Genetic Screen in Drosophila Larvae Links ird1 Function to Toll Signaling in the Fat Body and Hemocyte Motility.
PloS one - 1 Jan 2016
Schmid Martin R, Anderl Ines, Vo Hoa T M, Valanne Susanna, Yang Hairu, Kronhamn Jesper, Rämet Mika, Rusten Tor Erik, Hultmark Dan
Abstract excerpt
To understand how Toll signaling controls the activation of a cellular immune response in Drosophila blood cells (hemocytes), we carried out a genetic modifier screen, looking for deletions that suppress or enhance the mobilization of sessile hemocytes by the gain-of-function mutation Toll10b (Tl10b). Here we describe the results from chromosome arm 3R, where five regions strongly suppressed this phenotype. We...
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