Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Support for the N -Methyl-D-Aspartate Receptor Hypofunction Hypothesis of Schizophrenia From Exome Sequencing in Multiplex Families

4 Apr 2013

Abstract excerpt

IMPORTANCE: Schizophrenia is a complex genetic disorder demonstrating considerable heritability. Genetic studies have implicated many different genes and pathways, but much of the genetic liability remains unaccounted for. Investigation of genetic forms of schizophrenia will lead to a better understanding of the underlying molecular pathways, which will then enable targeted approaches for disease prevention and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic Associations and Epidemiology
Share to Genomic variations and chromosomal abnormalities
Share to Schizophrenia research and treatment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23553203
DOI: 10.1001/jamapsychiatry.2013.1195

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Support for the N -Methyl-D-Aspartate Receptor Hypofunction Hypothesis of Schizophrenia From Exome Sequencing in Multiplex FamiliesPMID 23553203Read ↗

Rare structural variants disrupt multiple genes in neurodevelopmental pathways in schizophrenia.Semantic proximity Read ↗

Molecular mechanisms of schizophrenia: Insights from human genetics.Semantic proximity Read ↗

Exome sequencing in families with severe mental illness identifies novel and rare variants in genes implicated in Mendelian neuropsychiatric syndromesSemantic proximity Read ↗

Exome sequences of multiplex, multigenerational families reveal schizophrenia risk loci with potential implications for neurocognitive performance.Semantic proximity Read ↗

Exome sequencing in families with severe mental illness identifies novel and rare variants in genes implicated in Mendelian neuropsychiatric syndromesSemantic proximity Read ↗

Rare Pathogenic Variants in Genes Implicated in Glutamatergic Neurotransmission Pathway Segregate with Schizophrenia in Pakistani Families.Semantic proximity Read ↗

Genetic risk for schizophrenia: convergence on synaptic pathways involved in plasticity.Semantic proximity Read ↗

The genomics of schizophrenia: update and implications.Semantic proximity Read ↗

Rare germline variants in individuals diagnosed with schizophrenia within multiplex families.Semantic proximity Read ↗

Association between schizophrenia and both loss of function and missense mutations in paralog conserved sites of voltage-gated sodium channelsSemantic proximity Read ↗

De novo mutations in schizophrenia implicate synaptic networks.Semantic proximity Read ↗

Exome sequencing identifies rare coding variants in 10 genes which confer substantial risk for schizophreniaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.