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Article

Association of SNPs in EGR3 and ARC with Schizophrenia Supports a Biological Pathway for Schizophrenia Risk.

PloS one - 1 Jan 2015

Huentelman Matthew J, Muppana Leela, Corneveaux Jason J, Dinu Valentin, Pruzin Jeremy J, Reiman Rebecca, Borish Cassie N, De Both Matt, Ahmed Amber, Todorov Alexandre, Cloninger C Robert, Zhang Rui, Ma Jie, Gallitano Amelia L

Abstract excerpt

We have previously hypothesized a biological pathway of activity-dependent synaptic plasticity proteins that addresses the dual genetic and environmental contributions to schizophrenia. Accordingly, variations in the immediate early gene EGR3, and its target ARC, should influence schizophrenia susceptibility. We used a pooled Next-Generation Sequencing approach to identify variants across these genes in U.S....

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Identifiers

PMID: 26474411
DOI: 10.1371/journal.pone.0135076
PMCID: PMC4608790

Genes

ARC
EGR3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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