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Article

Infantile spasms in down syndrome: Rescue by knockdown of the GIRK2 channel.

Annals of neurology - 1 Oct 2016

Joshi Krutika, Shen Lily, Michaeli Avner, Salter Michael, Thibault-Messier Gabrielle, Hashmi Sumaiya, Eubanks James H, Cortez Miguel A, Snead O Carter

Abstract excerpt

OBJECTIVE: The Ts65Dn (Ts) mouse model of Down syndrome (DS) is exquisitely sensitive to an infantile spasms phenotype induced by γ-aminobutyric acidB receptor (GABAB R) agonists. The Ts mouse contains the core genomic triplication of the DS critical region, which includes 3 copies of the Kcnj6 gene that encodes the GABAB R-coupled G protein-coupled inward rectifying potassium channel subunit 2 (GIRK2) channel....

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Identifiers

PMID: 27462820
DOI: 10.1002/ana.24749

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Infantile spasms in down syndrome: Rescue by knockdown of the GIRK2 channel.PMID 27462820Read ↗

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