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Article

The "Down syndrome critical region" is sufficient in the mouse model to confer behavioral, neurophysiological, and synaptic phenotypes characteristic of Down syndrome.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 6 May 2009

Belichenko Nadia P, Belichenko Pavel V, Kleschevnikov Alexander M, Salehi Ahmad, Reeves Roger H, Mobley William C

Abstract excerpt

Down syndrome (DS) can be modeled in mice segmentally trisomic for mouse chromosome 16. Ts65Dn and Ts1Cje mouse models have been used to study DS neurobiological phenotypes including changes in cognitive ability, induction of long-term potentiation (LTP) in the fascia dentata (FD), the density an...

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Identifiers

PMID: 19420260
DOI: 10.1523/JNEUROSCI.1547-09.2009
PMCID: PMC3849469

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19420260-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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