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Article

SMG7 is a critical regulator of p53 stability and function in DNA damage stress response

19 Jan 2016

Abstract excerpt

The p53 tumor suppressor functions as a transcription factor and plays a pivotal role in regulation of cellular response to DNA damage by activating various genes including those involved in cell cycle arrest. p53 stability is essential for its function during stress response; however, the molecular mechanism for DNA damage-induced stabilization of p53 is not fully understood. In our present study, we have...

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Identifiers

PMID: 27462439
DOI: 10.1038/celldisc.2015.42

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