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Article

VPS35 regulates cell surface recycling and signaling of dopamine receptor D1.

Neurobiology of aging - 1 Oct 2016

Wang Chen, Niu Mengxi, Zhou Zehua, Zheng Xiaoyuan, Zhang Lingzhi, Tian Ye, Yu Xiaojun, Bu Guojun, Xu Huaxi, Ma Qilin, Zhang Yun-Wu

Abstract excerpt

Vacuolar protein sorting 35 (VPS35) is a retromer complex component regulating membrane protein trafficking and retrieval. Mutations or dysfunction of VPS35 have been linked to Parkinson's disease (PD), which is pathologically characterized by the loss of dopamine neurons in brain substantia nigra region. Dopamine plays a key role in regulating various brain physiological functions by binding to its receptors and...

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Source

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Identifiers

PMID: 27460146
DOI: 10.1016/j.neurobiolaging.2016.05.016
PMCID: PMC5018432

Genes

VPS35
DRD1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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