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Parkinson's Disease Causative Mutation in Vps35 Disturbs Tetherin Trafficking to Cell Surfaces and Facilitates Virus Spread.

Cells - 28 Mar 2021

Ding Yingzhuo, Li Yan, Chhetri Gaurav, Peng Xiaoxin, Wu Jing, Wang Zejian, Zhao Bo, Zhao Wenjuan, Li Xueyi

Abstract excerpt

Parkinson's disease (PD) is the most common neurodegenerative movement disorder, characterized by progressive loss of dopaminergic neurons in the substantia nigra, intraneuronal deposition of misfolded proteins known as Lewy bodies, and chronic neuroinflammation. PD can arise from monogenic mutations, but in most cases, the etiology is unclear. Viral infection is gaining increasing attentions as a trigger of PD....

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Identifiers

PMID: 33800686
DOI: 10.3390/cells10040746
PMCID: PMC8066283

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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