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Article

Translation initiation at non-AUG codons mediated by weakened association of eukaryotic initiation factor (eIF) 2 subunits.

The Biochemical journal - 15 Oct 2002

Hashimoto Nilce N, Carnevalli Larissa S, Castilho Beatriz A

Abstract excerpt

The heterotrimeric eukaryotic initiation factor (eIF) 2 binds the initiator methionyl-tRNA in a GTP-dependent mode and delivers it to the 40 S ribosomal subunit. In the present study, we have identified amino acid residues in eIF2beta required for binding to eIF2gamma in yeast. Alteration of six residues in the central region of eIF2beta abolished this interaction, as determined by GST-pull down and two-hybrid...

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Identifiers

PMID: 12137565
DOI: 10.1042/BJ20020556
PMCID: PMC1222906

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Translation initiation at non-AUG codons mediated by weakened association of eukaryotic initiation factor (eIF) 2 subunits.PMID 12137565Read ↗

Translation initiation factor 2gamma mutant alters start codon selection independent of Met-tRNA binding.Semantic proximity Read ↗

Mutations in GCD11, the structural gene for eIF-2 gamma in yeast, alter translational regulation of GCN4 and the selection of the start site for protein synthesis.Semantic proximity Read ↗

The eIF1A C-terminal domain promotes initiation complex assembly, scanning and AUG selection in vivo.Semantic proximity Read ↗

Domains of eIF1A that mediate binding to eIF2, eIF3 and eIF5B and promote ternary complex recruitment in vivo.Semantic proximity Read ↗

eIF2A, an initiator tRNA carrier refractory to eIF2α kinases, functions synergistically with eIF5B.Semantic proximity Read ↗

Eukaryotic translation initiation factor eIF5 promotes the accuracy of start codon recognition by regulating Pi release and conformational transitions of the preinitiation complex.Semantic proximity Read ↗

β-Hairpin loop of eukaryotic initiation factor 1 (eIF1) mediates 40 S ribosome binding to regulate initiator tRNA(Met) recruitment and accuracy of AUG selection in vivo.Semantic proximity Read ↗

Dissociation of eIF1 from the 40S ribosomal subunit is a key step in start codon selection in vivo.Semantic proximity Read ↗

Mutations in Caenorhabditis elegans eIF2beta permit translation initiation from non-AUG start codons.Semantic proximity Read ↗

Interactions of eukaryotic translation initiation factor 3 (eIF3) subunit NIP1/c with eIF1 and eIF5 promote preinitiation complex assembly and regulate start codon selection.Semantic proximity Read ↗

Evidence for a Negative Cooperativity between eIF5A and eEF2 on Binding to the Ribosome.Semantic proximity Read ↗

Tight binding of the phosphorylated alpha subunit of initiation factor 2 (eIF2alpha) to the regulatory subunits of guanine nucleotide exchange factor eIF2B is required for inhibition of translation initiation.Semantic proximity Read ↗

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