Production of full-length soluble Plasmodium falciparum RH5 protein vaccine using a Drosophila melanogaster Schneider 2 stable cell line system.

doi:10.1038/srep30357

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Article

Production of full-length soluble Plasmodium falciparum RH5 protein vaccine using a Drosophila melanogaster Schneider 2 stable cell line system.

Scientific reports - 26 Jul 2016

Hjerrild Kathryn A, Jin Jing, Wright Katherine E, Brown Rebecca E, Marshall Jennifer M, Labbé Geneviève M, Silk Sarah E, Cherry Catherine J, Clemmensen Stine B, Jørgensen Thomas, Illingworth Joseph J, Alanine Daniel G W, Milne Kathryn H, Ashfield Rebecca, de Jongh Willem A, Douglas Alexander D, Higgins Matthew K, Draper Simon J

Abstract excerpt

The Plasmodium falciparum reticulocyte-binding protein homolog 5 (PfRH5) has recently emerged as a leading candidate antigen against the blood-stage human malaria parasite. However it has proved challenging to identify a heterologous expression platform that can produce a soluble protein-based vaccine in a manner compliant with current Good Manufacturing Practice (cGMP). Here we report the production of...

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PMID: 27457156
DOI: 10.1038/srep30357
PMCID: PMC4960544

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