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Article

E2F8 as a Novel Therapeutic Target for Lung Cancer

18 Jun 2015

Abstract excerpt

BACKGROUND: The E2F members have been divided into transcription activators (E2F1-E2F3) and repressors (E2F4-E2F8). E2F8 with E2F7 has been known to play an important physiologic role in embryonic development and cell cycle regulation by repressing E2F1. However, the function of E2F8 in cancer cells is unknown. METHODS: E2F8 expression was assessed by immunoblotting or immunofluorescence staining in human lung...

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PMID: 26089541
DOI: 10.1093/jnci/djv151

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