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Article

E2F8 Contributes to Human Hepatocellular Carcinoma via Regulating Cell Proliferation

12 Jan 2010

Abstract excerpt

The E2F family member of transcription factors includes the atypical member E2F8, which has been little studied in cancer. We report that E2F8 is strongly upregulated in human hepatocellular carcinoma (HCC), where it was evidenced to contribute to oncogenesis and progression. Ectopic overexpression of E2F8 promoted cell proliferation, colony formation, and tumorigenicity, whereas E2F8 knockdown inhibited these...

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PMID: 20068156
DOI: 10.1158/0008-5472.can-09-3082

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