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Article

E2F8 is a Potential Therapeutic Target for Hepatocellular Carcinoma

1 Jan 2017

Abstract excerpt

E2F transcriptional factors are widely expressed in a number of tissues and organs, possessing many regulatory functions related to cellular proliferation, differentiation, DNA repair, cell-cycle and cell apoptosis. E2F8 is a recently identified member of the E2F family with a duplicated DNA-binding domain feature discriminated from E2F1-6, controlling gene expression in a dimerization partner-independent manner....

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PMID: 28607595
DOI: 10.7150/jca.18255

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