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Article

Aldehyde dehydrogenase 2 is associated with cognitive functions in patients with Parkinson's disease.

Scientific reports - 25 Jul 2016

Yu Rwei-Ling, Tan Chun-Hsiang, Lu Ying-Che, Wu Ruey-Meei

Abstract excerpt

Neurotransmitter degradation has been proposed to cause the accumulation of neurotoxic metabolites. The metabolism of these metabolites involves aldehyde dehydrogenase 2 (ALDH2). The Asian-specific single nucleotide polymorphism rs671 causes reduced enzyme activity. This study aims to explore whether Parkinson's disease (PD) patients with reduced ALDH2 activity owing to the rs671 polymorphism are at risk for...

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Source

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Identifiers

PMID: 27453488
DOI: 10.1038/srep30424
PMCID: PMC4958972

Genes

ALDH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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