Article

Single-cell RNA binding protein regulatory network analyses reveal oncogenic HNRNPK-MYC signalling pathway in cancer

2022-08-09

Abstract excerpt

RNA-binding proteins (RBPs) are key players of gene expression and perturbation of RBP-RNA regulatory network has been observed in various cancer types. Here, we propose a computational method, RBPreg, to identify the RBP regulators by integration of single cell RNA-Seq (N = 233,591) and RBP binding data. Pan-cancer analyses suggest that RBP regulators exhibit cancer and cell specificity and perturbation of RBP re...

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Literature Corpus work: 64d71f0f-ebe5-5ca7-bdee-2aaeacef7223
DOI: 10.21203/rs.3.rs-1919283/v1

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