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Article

Lamin Mutations Accelerate Aging via Defective Export of Mitochondrial mRNAs through Nuclear Envelope Budding.

Current biology : CB - 8 Aug 2016

Li Yihang, Hassinger Linda, Thomson Travis, Ding Baojin, Ashley James, Hassinger William, Budnik Vivian

Abstract excerpt

Defective RNA metabolism and transport are implicated in aging and degeneration [1, 2], but the underlying mechanisms remain poorly understood. A prevalent feature of aging is mitochondrial deterioration [3]. Here, we link a novel mechanism for RNA export through nuclear envelope (NE) budding [4, 5] that requires A-type lamin, an inner nuclear membrane-associated protein, to accelerated aging observed in...

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Identifiers

PMID: 27451905
DOI: 10.1016/j.cub.2016.06.007
PMCID: PMC4999898

Genes

LMNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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