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Article

Lamin A variants that cause striated muscle disease are defective in anchoring transmembrane actin-associated nuclear lines for nuclear movement.

Proceedings of the National Academy of Sciences of the United States of America - 4 Jan 2011

Folker Eric S, Ostlund Cecilia, Luxton G W Gant, Worman Howard J, Gundersen Gregg G

Abstract excerpt

Mutations in LMNA, which encodes A-type lamins, result in disparate diseases, known collectively as laminopathies, that affect distinct tissues, including striated muscle and adipose tissue. Lamins provide structural support for the nucleus and sites of attachment for chromatin, and defects in th...

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Identifiers

PMID: 21173262
DOI: 10.1073/pnas.1000824108
PMCID: PMC3017140

Genes

LMNA
SUN2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21173262-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

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Lamin A variants that cause striated muscle disease are defective in anchoring transmembrane actin-associated nuclear lines for nuclear movement.PMID 21173262Read ↗

Nesprins anchor kinesin-1 motors to the nucleus to drive nuclear distribution in muscle cells.Semantic proximity Read ↗

Broken nuclei--lamins, nuclear mechanics, and disease.Semantic proximity Read ↗

The nuclear lamina and inherited disease.Semantic proximity Read ↗

Nuclear migration events throughout development.Semantic proximity Read ↗

LMNA variants cause cytoplasmic distribution of nuclear pore proteins in Drosophila and human muscle.Semantic proximity Read ↗

Muscular dystrophy-associated SUN1 and SUN2 variants disrupt nuclear-cytoskeletal connections and myonuclear organization.Semantic proximity Read ↗

Mutant lamins cause nuclear envelope rupture and DNA damage in skeletal muscle cellsSemantic proximity Read ↗

Myopathic lamin mutations impair nuclear stability in cells and tissue and disrupt nucleo-cytoskeletal coupling.Semantic proximity Read ↗

Mutations in LMNA Modulate the Lamin A - Nesprin-2 Interaction and Cause LINC Complex AlterationsSemantic proximity Read ↗

A lamin A/C variant causing striated muscle disease provides insights into filament organization.Semantic proximity Read ↗

Eliminating elevated p53 signaling fails to rescue skeletal muscle defects or extend survival in Lamin A/C-deficient miceSemantic proximity Read ↗

A lamin A/C variant causing striated muscle disease provides insights into filament organizationSemantic proximity Read ↗

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