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Article

TERT promoter mutations and melanoma survival: A comprehensive literature review and meta-analysis.

Critical reviews in oncology/hematology - 1 Apr 2021

Gandini Sara, Zanna Ines, De Angelis Simone, Palli Domenico, Raimondi Sara, Ribero Simone, Masala Giovanna, Suppa Mariano, Bellerba Federica, Corso Federica, Nezi Luigi, Nagore Eduardo, Caini Saverio

Abstract excerpt

We conducted a systematic review and meta-analysis of the association between somatic mutations of the TERT gene promoter and melanoma survival. Data from nineteen independent studies (>2,500 melanoma overall) were pooled using random effects meta-analysis models. TERT-mutated melanoma patients had a significantly worse overall survival (OS) (summary hazard ratio 1.43, 95 % confidence intervals (CI) 1.05-1.95)...

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PMID: 33675908
DOI: 10.1016/j.critrevonc.2021.103288

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