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Article

Coexistence of TERT promoter and BRAF mutations in cutaneous melanoma is associated with more clinicopathological features of aggressiveness.

Virchows Archiv : an international journal of pathology - 1 Aug 2015

Macerola Elisabetta, Loggini Barbara, Giannini Riccardo, Garavello Giulia, Giordano Mirella, Proietti Agnese, Niccoli Cristina, Basolo Fulvio, Fontanini Gabriella

Abstract excerpt

The recently described telomerase reverse transcriptase (TERT) promoter mutations are recurrent in cutaneous melanoma. Several authors have described an association between these molecular alterations, some histological parameters, and patient survival. BRAF mutations are very frequent in melanoma, but their actual role in the evolution of the disease is still unclear. Here, we investigated the relationship of...

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Share to Disease Progression
Share to DNA Mutational Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Melanoma

Share to Promoter Regions, Genetic

Share to Proto-Oncogene Proteins B-raf

Share to Reverse Transcriptase Polymerase Chain Reaction

Share to Skin Neoplasms

Share to Telomerase

Source

Identifiers

PMID: 26055532
DOI: 10.1007/s00428-015-1784-x

Genes

BRAF
TERT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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