Article
Modulation of mesenchymal stem cell genotype and phenotype by extracellular matrix proteins.
Connective tissue research - 1 Nov 2016
Clements Lucy E, Garvican Elaine R, Dudhia Jayesh, Smith Roger K W
Abstract excerpt
AIM: To investigate the effect of extracellular matrix (ECM) proteins on characteristics of mesenchymal stem cells (MSCs) and tendon-derived cells (TDCs). MATERIALS AND METHODS: MSCs and TDCs, cultured in a monolayer (2D) or hydrogels (3D), with or without ECM protein supplementation, and on a non-viable native tendon (NNT) matrix were assayed for adhesion, proliferation, gene expression, and integrin expression....
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