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Article

Gene regulation of extracellular matrix remodeling in human bone marrow stem cell-seeded tissue-engineered grafts.

Tissue engineering. Part A - 1 Oct 2011

Emani Sirisha, Mayer John E, Emani Sitaram M

Abstract excerpt

Tissue-engineered heart valves are prone to early structural deterioration. We hypothesize that cell-scaffold interaction and mechanical deformation results in upregulation of genes related to osteogenic/chondrogenic differentiation and thus changes extracellular matrix (ECM) composition in human bone marrow mesenchymal stem cell (hBMSC)-derived tissue-engineered grafts. hBMSC were expanded and seeded onto...

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Source

Identifiers

PMID: 21554191
DOI: 10.1089/ten.TEA.2010.0628

Genes

TEC
ALPL
BMP2
EDN1
MGP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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