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Article

Serum deprivation limits loss and promotes recovery of tenogenic phenotype in tendon cell culture systems.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society - 1 Jul 2021

van Vijven Marc, Wunderli Stefania L, Ito Keita, Snedeker Jess G, Foolen Jasper

Abstract excerpt

Current knowledge gaps on tendon tissue healing can partly be ascribed to the limited availability of physiologically relevant culture models. An unnatural extracellular matrix, high serum levels and random cell morphology in vitro mimic strong vascularization and lost cell elongation in pathology, and discord with a healthy, in vivo cell microenvironment. The thereby induced phenotypic drift in tendon-derived...

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Identifiers

PMID: 32478872
DOI: 10.1002/jor.24761
PMCID: PMC8359397

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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