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Article

Mesenchymal Stem Cells Downregulate Articular Chondrocyte Differentiation in Noncontact Coculture Systems: Implications in Cartilage Tissue Regeneration

9 Jan 2013

Abstract excerpt

While chondrogenesis of mesenchymal stem cells (MSCs) in vitro has been extensively studied, their participation in cartilage tissue repair remains unresolved. This study was designed to elucidate if MSCs affect the phenotype of articular chondrocytes (ACs). A combination of noncontact coculture modes was developed. Human or rabbit MSCs and rabbit ACs (rACs) were encapsulated in alginate hydrogel beads...

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PMID: 23301843
DOI: 10.1089/scd.2012.0605

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