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Article

Paracrine interactions between mesenchymal stem cells affect substrate driven differentiation toward tendon and bone phenotypes.

PloS one - 1 Jan 2012

Sharma Ram I, Snedeker Jess G

Abstract excerpt

We investigated substrate dependent paracrine signaling between subpopulations of bone marrow stromal cells (BMSCs) that may affect the formation, or perhaps malformation, of the regenerating tendon to bone enthesis. Polyacrylamide substrates approximating the elastic modulus of tendon granulation tissue and the osteoid of healing bone (10-90 kPa) were functionalized with whole length fibronectin (Fn), type-I...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 22355373
DOI: 10.1371/journal.pone.0031504
PMCID: PMC3280320

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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