Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A transgenic rabbit model for human hypertrophic cardiomyopathy

15 Dec 1999

Abstract excerpt

Certain mutations in genes for sarcomeric proteins cause hypertrophic cardiomyopathy (HCM). We have developed a transgenic rabbit model for HCM caused by a common point mutation in the beta-myosin heavy chain (MyHC) gene, R400Q. Wild-type and mutant human beta-MyHC cDNAs were cloned 3' to a 7-kb murine beta-MyHC promoter. We injected purified transgenes into fertilized zygotes to generate two lines each of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cardiomyopathy and Myosin Studies
Share to Cardiovascular Effects of Exercise
Share to Viral Infections and Immunology Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 10606622
DOI: 10.1172/jci7956

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A transgenic rabbit model for human hypertrophic cardiomyopathyPMID 10606622Read ↗

Animal models of hypertrophic cardiomyopathy.Semantic proximity Read ↗

Tissue Doppler imaging consistently detects myocardial contraction and relaxation abnormalities, irrespective of cardiac hypertrophy, in a transgenic rabbit model of human hypertrophic cardiomyopathy.Semantic proximity Read ↗

[Application of transgenic animal in hypertrophic cardiomyopathy].Semantic proximity Read ↗

A truncated cardiac troponin T molecule in transgenic mice suggests multiple cellular mechanisms for familial hypertrophic cardiomyopathy.Semantic proximity Read ↗

Evolution of expression of cardiac phenotypes over a 4-year period in the beta-myosin heavy chain-Q403 transgenic rabbit model of human hypertrophic cardiomyopathy.Semantic proximity Read ↗

Comparison of two murine models of familial hypertrophic cardiomyopathy.Semantic proximity Read ↗

Transgenic rabbits expressing mutant essential light chain do not develop hypertrophic cardiomyopathy.Semantic proximity Read ↗

Age-related changes in familial hypertrophic cardiomyopathy phenotype in transgenic mice and humans.Semantic proximity Read ↗

A mouse model of familial hypertrophic cardiomyopathy.Semantic proximity Read ↗

Transgenic rabbit models for cardiac disease researchSemantic proximity Read ↗

A mouse model of myosin binding protein C human familial hypertrophic cardiomyopathy.Semantic proximity Read ↗

A One Health Approach to Hypertrophic Cardiomyopathy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.