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Article

L-3-n-butylphthalide Rescues Hippocampal Synaptic Failure and Attenuates Neuropathology in Aged APP/PS1 Mouse Model of Alzheimer's Disease.

CNS neuroscience & therapeutics - 1 Dec 2016

Zhang Yu, Huang Long-Jian, Shi Si, Xu Shao-Feng, Wang Xiao-Liang, Peng Ying

Abstract excerpt

AIMS: Our previous studies showed that L-3-n-butylphthalide (L-NBP), an extract from seeds of Apium graveolens Linn (Chinese celery), improved cognitive ability in animal models of cerebral ischemia, vascular dementia, and Alzheimer's disease (AD). It is well known that cognitive deficit of AD is caused by synaptic dysfunction. In this study, we investigated the effect of L-NBP on hippocampal synaptic function in...

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Source

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Identifiers

PMID: 27439966
DOI: 10.1111/cns.12594
PMCID: PMC6492814

Genes

APP
PSD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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