Article
L-3-n-Butylphthalide Regulates Proliferation, Migration, and Differentiation of Neural Stem Cell In Vitro and Promotes Neurogenesis in APP/PS1 Mouse Model by Regulating BDNF/TrkB/CREB/Akt Pathway.
Neurotoxicity research - 1 Oct 2018
Lei Hui, Zhang Yu, Huang Longjian, Xu Shaofeng, Li Jiang, Yang Lichao, Wang Ling, Xing Changhong, Wang Xiaoliang, Peng Ying
Abstract excerpt
Alzheimer's disease (AD) is characterized by extracellular accumulation of β-amyloid peptides (Aβ) and intracellular neurofibrillary tangles, along with cognitive decline and neurodegeneration. The cognitive deficit is considered to be due to the dysfunction of hippocampal neurogenesis. Although L-3-n-butylphthalide (L-NBP) has been shown beneficial effects in multiple AD animal models, the underlying molecular...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.