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Article

Colivelin Ameliorates Impairments in Cognitive Behaviors and Synaptic Plasticity in APP/PS1 Transgenic Mice.

Journal of Alzheimer's disease : JAD - 1 Jan 2017

Wu Meina, Shi Hui, He Yexin, Yuan Li, Qu Xuesong, Zhang Jun, Wang Zhaojun, Cai Hongyan, Qi Jinshun

Abstract excerpt

Alzheimer's disease (AD) is the most common cause of dementia, and effective therapeutics are lacking. Colivelin (CLN), a novel, strong humanin derivative, is effective in vitro in preventing cell death induced by AD-causative genes and amyloid-β protein (Aβ) even at a low concentration. We recently demonstrated that intrahippocampal injection of CLN prevents Aβ25-35-induced deficits in spatial memory and...

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Source

Identifiers

PMID: 28731445
DOI: 10.3233/JAD-170307

Genes

APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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