Article
PIK3CA exon 20 mutations as a potential biomarker for resistance to anti-EGFR monoclonal antibodies in KRAS wild-type metastatic colorectal cancer: a systematic review and meta-analysis.
Annals of oncology : official journal of the European Society for Medical Oncology - 1 Jun 2012
Mao C, Yang Z Y, Hu X F, Chen Q, Tang J L
Abstract excerpt
BACKGROUND: We conducted a systematic review and meta-analysis to dissect the association between PIK3CA mutations and resistance to anti-epidermal growth factor receptor (EGFR) monoclonal antibodies (MoAbs) according to PIK3CA exon of mutations in metastatic colorectal cancer (mCRC). METHODS: We systematically identified studies exploring the association between PIK3CA mutations and clinical outcomes of mCRC...
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