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Article

Clinical Impact of PI3K/BRAF Mutations in RAS Wild Metastatic Colorectal Cancer: Meta-analysis Results.

Journal of gastrointestinal cancer - 1 Jun 2019

Mohamed Amr, Twardy Brandon, AbdAllah Nadine, Akhras Alaa, Ismail Hibah, Zordok Magdi, Schrapp Kelly, Attumi Taraq, Tesfaye Anteneh, El-Rayes Bassel

Abstract excerpt

BACKGROUND: Understanding the molecular mechanisms of colorectal cancer has evolved during the last decade ushering the era of personalized medicine. Alteration of BRAF and PI3K is common in colorectal cancer, and can affect several signaling pathways including EGFR (epidermal growth factor receptor). The aim of this meta-analysis is to evaluate the clinical role of PI3K and BRAF mutations in patients with KRAS...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29388061
DOI: 10.1007/s12029-018-0062-y

Genes

BRAF
EGFR
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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