Article
A20 SNP rs77191406 may be related to secondary cancer for rheumatoid arthritis and systemic lupus erythematosus patients.
Asia-Pacific journal of clinical oncology - 1 Dec 2016
Zhu Lihua, Zhou Lingling, Wang Liang, Li Zhaoxia, Lu Shuai, Yang Lijian, Chen Shaohua, Li Bo, Wu Xiuli, Zhou Yi, Li Yangqiu
Abstract excerpt
AIM: An increased risk for malignancy for rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) patients may be related to factors that play a critical role in the regulation of T-cell activation. A20 is an important negative immunoregulatory factor that was found to be associated with lymphoma and the development of numerous solid tumors. Previous studies have implicated the A20 locus in RA...
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