Article
p21 gene polymorphisms in systemic lupus erythematosus.
Rheumatology (Oxford, England) - 1 Feb 2007
Kong E K-P, Chong W-P, Wong W H-S, Lau C-S, Chan T-M, Ng P K-M, Song Y-Q, Mak W, Lau Y-L
Abstract excerpt
OBJECTIVE: Cyclin-dependent kinase inhibitor 1A (p21) is a negative regulator in the cell cycle. Development of sex-linked lupus-like syndrome in p21-/- mice and reduced p21 gene expression in patients with systemic lupus erythematosus (SLE) compared with those in healthy controls suggested that p21 is a susceptibility gene of SLE. We investigated the same by a case-control association study. METHODS: Six single...
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