Higher incidence of the SNP Met 788 Ile in the coding region of A20 in diffuse large B cell lymphomas.

doi:10.1007/s13277-015-4322-1

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Article

Higher incidence of the SNP Met 788 Ile in the coding region of A20 in diffuse large B cell lymphomas.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Apr 2016

Wenzl Kerstin, Hofer Sybille, Troppan Katharina, Lassnig Markus, Steinbauer Elisabeth, Wiltgen Marco, Zulus Barbara, Renner Wilfried, Beham-Schmid Christine, Neumeister Peter, Deutsch Alexander

Abstract excerpt

Genetic alterations causing constitutive activation of the nuclear factor kappa B (NF-κB) signaling pathway has been associated with the development of lymphomas. A20 (TNFAIP3) is a key regulator of NF-κB signaling. Its suppressor functions are often inactivated by deletions and/or mutations in various hematologic malignancies. Since we recently found the rs143002189 polymorphism in the A20 loci in our multiple...

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PMID: 26518771
DOI: 10.1007/s13277-015-4322-1

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TNFAIP3

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