Article
Different genetic alteration of A20 in a Sézary syndrome case with Vα2-Jα22 T cell clone.
Asia-Pacific journal of clinical oncology - 1 Apr 2018
Zhou Lingling, Zheng Haitao, Huang Xin, Zhu Lihua, Wu Suijing, Zeng Chengwu, Yang Lijian, Chen Shaohua, Luo Gengxin, Du Xin, Li Yangqiu
Abstract excerpt
BACKGROUND: The comprehensive genetic alterations underlying the pathogenesis of Sézary syndrome (SS) remains largely unknown. Previous studies showed that alterations of tumor necrosis factor-α-induced protein 3 gene (TNFAIP3; A20) are frequent in SS. In this study, we characterized the mutation and polymorphisms of A20 in a case with SS and compared with the genetic feature of A20 in T-cell acute lymphoblastic...
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